Mostrant 1 a 20 de 134 resultats
DataTítolAutor(s)Tipus
2022Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3Castellvi Toledo, Albert;Pequerul Pavon, Raquel;Barracco, Vito;Juanhuix, Judith;Pares Casasampera, Xavier;Farres Vicen, JaimeArticle
2021Perspective on the structural basis for human aldo-keto reductase 1b10 inhibitionPares Casasampera, Xavier;Farres Vicen, Jaime;Ruiz, Francesc XavierArticle
2021Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 InhibitorsPares Casasampera, Xavier;Farres Vicen, Jaime;Ibrahim, Ali I. M.;Ikhmais, Balqis;Batlle, Elisabet;Abuharb, Waed K.;Jha, Vibhu;Jaradat, Khaled T.;Jiménez, Rafael;Pequerul, Raquel;Pors, KlausArticle
2019Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiationPares Casasampera, Xavier;Farres Vicen, Jaime;Castellví Toledo, Albert;Crespo, Isidro;Crosas, Eva;Cámara-Artigas, Ana;Gavira, José A.;Aranda, Miguel A. G.;Juanhuix, JudithArticle
2017Carbon-carbon double-bond hydrogenation of 15-deoxy-Δ12,14-prostaglandin J2 by human prostaglandin reductase 1: Product identification by 1H and 13C NMR spectroscopy and catalytic mechanismMesa, Julio;Porté, Sergio;Cabañas, Miquel;Jaime Cardiel, Carles;Pares Casasampera, Xavier;Virgili Moya, AlbertArticle
2016Enantioselective synthesis of vicinal R,R-diols by Saccharomyces cerevisiae butanediol dehydrogenaseCalam, Eduard;González-Roca, Eva;Fernandez Gallegos, Maria Rosario;Dequin, Sylvie;Pares Casasampera, Xavier;Virgili Moya, Albert;Biosca Vaque, Josep AntoniArticle
2015Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10Ruiz, Francesc X.;Cousido-Siah, Alexandra;Domínguez, Marta;Crespo, Isidro;Rechlin, Chris;Mitschler, André;de Lera, Angel R.;Martín, María Jesús;De La Fuente, Jesús Ángel;Klebe, Gerhard;Pares Casasampera, Xavier;Farres Vicen, Jaime;Podjarny, AlbertoArticle
2015Substrate specificity, inhibitor selectivity and structure-function relationships of aldo-keto reductase 1B15: A novel human retinaldehyde reductaseKoláø, Michal H.;Ruiz, Francesc X.;Crespo, Isidro;Cousido-Siah, Alexandra;Podjarny, Alberto;Barski, Oleg A.;Fanfrlík, Jindøich;Pares Casasampera, Xavier;Farres Vicen, JaimeArticle
2015Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10Cousido-Siah, Alexandra;Ruiz, Francesc X.;Crespo, Isidro;Mitschler, André;Pares Casasampera, Xavier;Podjarny, Alberto;Farres Vicen, JaimeArticle
2015Human prostaglandin reductase 1 PGR1: Substrate specificity, inhibitor analysis and site-directed mutagenesisMesa, Julio;Alsina, Cristina;Oppermann, Udo;Pares Casasampera, Xavier;Farres Vicen, JaimeArticle
2014The Xenopus alcohol dehydrogenase gene family: Characterization and comparative analysis incorporating amphibian and reptilian genomesAlbalat, Ricard;Duester, Gregg;Pares Casasampera, Xavier;Farres Vicen, JaimeArticle
2014A missense mutation in ALDH1A3 causes isolated microphthalmia/anophthalmia in nine individuals from an inbred Muslim kindredMory, Adi;Ruiz, Francesc X.;Dagan, Efrat;Kurolap, Alina;Pares Casasampera, Xavier;Farres Vicen, Jaime;Gershoni-Baruch, RuthArticle
2014Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: Structure determination of both ternary complexes and implications for drug designCousido-Siah, Alexandra;Ruiz, Francesc X.;Mitschler, André;de Lera, Angel R.;Martin, Maria J.;Manzanaro, Sonia;De La Fuente, Jesús A.;Terwesten, Felix;Betz, Michael;Klebe, Gerhard;Farres Vicen, Jaime;Pares Casasampera, Xavier;Podjarny, AlbertoArticle
2013X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP+ and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivityRUIZ, FX;COUSIDO-SIAH, A;MITSCHLER, A;Farres Vicen, Jaime;Pares Casasampera, Xavier;PODJARNY, AArticle
2013Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo-keto reductasesFarres Vicen, Jaime;Fernandez Gallegos, Maria Rosario;Pares Casasampera, XavierArticle
2013Aldo-keto reductases in retinoid metabolism: Search for substrate specificity and inhibitor selectivityPORTÉ, S;XAVIER, RUIZ F;Giménez, J.;MOLIST, I;Álvarez, S.;DOMÍNGUEZ, M;Álvarez, R.;DE, LERA AR;Pares Casasampera, Xavier;Farres Vicen, JaimeArticle
2012Biological role of aldo-keto reductases in retinoic acid biosynthesis and signalingRuiz, F. Xavier;Pares Casasampera, Xavier;Farres Vicen, JaimeArticle
2011Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallinMoeini ., Agrin;Reche, Irene;Shafqat, Naeem;Oppermann, Udo;Farres Vicen, Jaime;Pares Casasampera, XavierArticle
2011Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehydeRUIZ, FX;MORO, A;Gallego, O;ARDÈVOL, A;Rovira, C.;PETRASH, JM;Pares Casasampera, Xavier;Farres Vicen, JaimeArticle
2011Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamilyRuiz, F. Xavier;Gallego, Oriol;Moro, Armando;Ardèvol, Albert;Del Río-Espínola, Alberto;Rovira, Carme;Farres Vicen, Jaime;Pares Casasampera, XavierArticle